A Kaplan-Meier analysis was performed to identify the time interval between TAE and early rebleeding.
Laparoscopic Colon Resection Surgery Patient Information from SAGES
Statistical analysis was performed using SPSS ver. Released All the patients showed no signs of bleeding on post-embolization angiography. Among the nine patients with clinical failure, four underwent repeated TAE at the sites of active bleeding, which had been previously embolized. The procedure protocol for the repeated TAE was the same as that for the first TAE, except for the different embolic agents that were used in three patients Table 3. Among the remaining five patients, three patients underwent colonoscopy. For one patient, electrocoagulation was performed at the site of active bleeding, which was in the same anatomic region as the embolization site.
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Two patients showed no sites of active bleeding or suspicious sites on colonoscopy, so conservative management was indicated. These seven patients who underwent endoscopy or embolization after early rebleeding did not show further rebleeding. The other two patients with clinical failure expired within 30 days. One patient with underlying chronic kidney disease and hypertension underwent TAE at the jejunal branch of the superior mesenteric artery.
Temporary hemostasis was achieved immediately after TAE; however, continuous hematochezia recurred soon thereafter. His condition worsened because of hypovolemia and metabolic acidosis, and he expired one day after TAE. The other patient, who had liver cirrhosis, diabetes, and hypertension, underwent TAE at the cecal branch of the right colic artery. Successful hemostasis was achieved for nine days. However, during these nine days, his condition worsened due to septic shock and disseminated intravascular coagulation. On the 10th day after TAE, hematochezia recurred and esophageal variceal bleeding developed.
Despite intensive medical management, he expired 21 days after TAE. The average and median time intervals between TAE and early rebleeding were approximately three days and one day, respectively. An overview of the nine patients with clinical failure is presented in Table 3.
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Delayed rebleeding occurred in four patients after TAE. The median interval between TAE and delayed rebleeding was days range - days.
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Two patients had angiodysplasia, and two had unknown etiologies of LGI bleeding. For the patient with angiodysplasia in the terminal ileum, angiography revealed that the site of active bleeding was the prior embolization site. After the repeated TAE, no rebleeding occurred.
In the other patient with angiodysplasia, a different bleeding site was disclosed on endoscopy and successful endoscopic electrocoagulation was performed.
One patient with an unknown etiology of LGI bleeding underwent endoscopic clipping and electrocoagulation at the site of active bleeding, which was in the same anatomic region as the prior embolization. The remaining one patient with an unknown etiology of LGI bleeding was treated conservatively without angiography or endoscopy. In one patient, TAE was performed at both the marginal artery and the vasa recta Table 4. The time interval from cessation of the anticoagulant or antiplatelet medication to embolization was within seven days median 1.
In the logistic regression analysis, the older the patients, the better their chances of clinical success odds ratio 1.
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Gelatin sponge embolization had a higher success rate than that achieved by microcoil embolization, and borderline significance was observed odds ratio 7. Sex, underlying disease, anticoagulant or antiplatelet medication, and embolization site were not statistically significant factors Table 5. The patient was a year-old man who was hospitalized for sepsis and had underlying liver cirrhosis. Superior mesenteric arteriography revealed hypervascularity at the cecum and terminal ileum.
Gelatin sponge embolization was performed at the level of the vasa recta, and bleeding stopped. A few days after TAE, endoscopy revealed bowel ischemia. On the eighth day after TAE, he expired from the worsened septic condition. Since TAE for intra-abdominal bleeding was introduced in 15 , it has been considered a good alternative therapeutic method when gastrointestinal bleeding is refractory or impossible to treat with endoscopy.
Advances in microcatheter systems have made superselective TAE possible and decreased complications, including bowel ischemia and recurrent bleeding via collateral flow. Generally, technical difficulty, vasospasm, and prior surgery are the causes of embolization failure However, no such obstacles affected the outcomes of embolization in the present study. In the nine patients classified as clinical failures, the time interval between TAE and early rebleeding was usually short, and the average was approximately three days. Other studies also showed relatively short time intervals, within one day or an average three days 17 , The prior embolization site was the site of rebleeding in five patients.
Other studies also show the rebleeding site after TAE to be the site of the prior TAE, which can be explained by collateral blood flow or the insufficient reduction of pulse pressure 24 , Some studies point out that the etiology of LGI bleeding is the most important factor in delayed rebleeding 2 , 19 , Angiodysplasia is the most common cause of delayed rebleeding 18 , 26 , Other frequently attributed lesions are extensive diverticulosis and tumors that can progress or metastasize 2 , 19 , Angiodysplasia could have been the cause of the delayed rebleeding in two patients, although no investigation into the causes of rebleeding was conducted.
However, the precise deployment of microcoil TAE requires radiologists with a high skill level and experience. Difficulties in the precise deployment and incomplete control of the distal blood flow can be attributed to clinical failure.
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In some cases, supplementary embolization using PVA particles or a gelatin sponge may be necessary to consolidate the coil-embolized artery after microcoil deployment 2 , 29 - In our series, a gelatin sponge was used as the supplementary embolic material in 16 patients.
A gelatin sponge, the most commonly used embolic agent in this study, is widely used because it is safe, inexpensive, and easy to use 2. Although no statistically significant differences in success rates were observed between the microcoil and gelatin sponge groups, the gelatin sponge group had a higher success rate.
In the gelatin sponge group, marginal artery embolization was performed in 15 out of 25 cases. However, marginal artery embolization was performed in two out of 20 cases in the microcoil group. Therefore, we can speculate that a gelatin sponge could effectively prevent rebleeding from backflow via collateral circulation, even in marginal artery embolization. Also, supplemental particle embolization after microcoil deployment may be helpful in controlling LGI bleeding. Davos offers quite a large number of private apartments at reasonable rates for small groups or families from 3 to 6 persons.
Usually, the rent of private apartments does not include costs for the cleaning and other in-house services. Private apartments are usually booked out by the end of October. Therefore reservations with corresponding prepayment should be made as soon as possible by contact Davos Congress at Talstrasse 41, CH Davos Platz, E-Mail: info davoscongress. In case of cancellation of your accommodation hotel or private apartments for any reason, the course organisation will not be responsible and cannot take over any legal responsibilities. The cancellation policy according to your specific reservation contract on the confirmation form will apply.
Cancellations of hotel accommodation or private apartments must be made to Davos Congress or to the hotel directly refer to confirmation of accommodation. The course will not take over any responsibilities at all. Take exit Landquart and follow the valley road Nr. Winter equipment chains might be needed. Parking overnight on street parkings or open-air public parkings is not allowed in Davos.
texprepbersno.tk Travellers arriving by plane at Zurich Airport can reach the airport train station by a short walk of some meters. Tickets can be purchased at the airport train station on site or on-line in advance.
At main station a first change of the train with final destination Chur is required. When reaching Landquart shortly before Chur, a second change to the local train red colored will be necessary. For train connections, please consult the Swiss railway homepage at www. Without the tremendous support of the sponsoring companies who are not only providing all needed laparoscopic equipment, suturing material and one way material but also bearing part of the infrastructural costs, the courses would not be possible.
Info The Davos Course for gastrointestinal surgery offers a varied and manifold programme of scientific sessions and practical exercises to surgeons in training.
Scientific Program The Davos Course offers three different levels of skills training and corresponding lectures , each consisting of two modules. Laparoscopic surgery module: Learning of basic laparoscopic techniques. In such instances bibliographic references have been provided for ready reference. The bibliography emphasizes recent contributions because they are easily available to the reader.